{"created":"2023-06-20T14:05:33.487924+00:00","id":40566,"links":{},"metadata":{"_buckets":{"deposit":"6532823c-51d8-49b8-a7c9-a221c596b4eb"},"_deposit":{"created_by":14,"id":"40566","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"40566"},"status":"published"},"_oai":{"id":"oai:soka.repo.nii.ac.jp:00040566","sets":["3813:6958:6959"]},"author_link":["93843","93844"],"item_4_date_granted_10":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-01-30"}]},"item_4_degree_grantor_8":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"創価大学"}]}]},"item_4_degree_name_7":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（工学）"}]},"item_4_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マウス胚幹細胞細胞（ESCs）およびエピブラスト様細胞（EpiLCs）は、in vitro で胚の初期発生を再現\nする多能性幹細胞（PSCs）であり、ESCsであるナイーブ状態のPSCsからEpiLCsであるプライム状態の\nPSCs への遷移メカニズムの解明を可能するモデルとなる。はじめに、ESCs とEpiLCs の網羅的糖鎖プロ\nファイリングを行い、糖鎖構造が発生の初期段階から劇的な変化を遂げることを明らかにした。この変\n化は、クロマチンリモデラーであるpolycomb repressive complex 2 (PRC2)によって制御されており、\n全体の糖鎖構造を調節するネットワークの存在を見出した。さらに、ESCsにおける糖鎖の機能解析も行\nい、O-結合型でムチン型糖鎖の一種であるT 抗原（Galβ1-3GalNAc）とその構造を合成するC1galt1 が\nESCsの多能性の維持に関与していることを示した。本研究では、多能性の状態遷移中に発生する糖鎖の\nダイナミクスを明らかにし、糖鎖によるESCs多能性の制御メカニズムを特定した。","subitem_description_type":"Abstract"}]},"item_4_dissertation_number_11":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第177号"}]},"item_4_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Pecori, 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MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"kogakukenkyuka_Pecori-Federico(zen).pdf","url":"https://soka.repo.nii.ac.jp/record/40566/files/kogakukenkyuka_Pecori-Federico(zen).pdf"},"version_id":"e2802bcf-175c-450c-baa5-4c8c485c8215"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pluripotent stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":" glycomics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":" epigenetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mucin-type O-glycosylation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt signaling","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"マウス多能性幹細胞における網羅的糖鎖プロファイリングと機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス多能性幹細胞における網羅的糖鎖プロファイリングと機能解析","subitem_title_language":"ja"},{"subitem_title":"Characterization and functional analysis of glycosylation in mouse pluripotent stem cells","subitem_title_language":"en"}]},"item_type_id":"4","owner":"14","path":["6959"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-10"},"publish_date":"2021-04-10","publish_status":"0","recid":"40566","relation_version_is_last":true,"title":["マウス多能性幹細胞における網羅的糖鎖プロファイリングと機能解析"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2024-02-01T06:47:39.334830+00:00"}